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Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein

Identifieur interne : 001D02 ( Main/Exploration ); précédent : 001D01; suivant : 001D03

Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein

Auteurs : Vladimir A. Slepushkin [États-Unis] ; Jacqueline M. Katz [États-Unis] ; Renee A. Black [États-Unis] ; William C. Gamble [États-Unis] ; Paul A. Rota [États-Unis, Russie] ; Nancy J. Cox [États-Unis]

Source :

Vaccine [ 0264-410X ] ; 1995.

RBID : ISTEX:0585156783CE56219023EC793EDA57CD8BBF1A4A

English descriptors

Teeft :
- Antibody response, Arbor, Arbor virus, Blot analysis, Clifton road, Disease control, Heterologous virus, Heterosubtypic immunity, Infectious diseases, Influenza, Influenza type, Influenza virus, Influenza viruses, Insect cells, Lassa virus, Lethal challenge, Lethal infection, Mice vaccinated, Mouse, Mouse lungs, National center, Peptide, Protective effect, Significant reduction, Synthetic peptides, Vaccinated, Vaccinated mice, Vaccination, Vaccine, Vaccine group, Viral, Viral infection, Virus, Virus replication, Weight loss, Whole virus.

Abstract

Abstract: We have investigated the potential of the conserved transmembrane M2 protein of influenza A/Ann Arbor/6/60 virus, expressed by a baculovirus recombinant, to induce protective immunity in BALB c mice. Vaccination of mice with shortened the duration of virus shedding and protected mice from a lethal infection with A/Ann Arbor/6/60 virus but not B/Ann Arbor/1/55 virus, suggesting that the protection was mediated by an M2-specific mechanism. Serum antibodies were detected which reacted with synthetic peptides defining three antigenic determinants located on both the external N- and internal C-termini of the M2 protein. Furthermore, vaccination with M2 protected mice from death following a lethal challenge with the heterologous A/Hong Kong/68 (H3N2) virus. These results demonstrate the potential to elicit heterosubtypic immunity to type A influenza viruses through vaccination with a conserved transmembrane protein.

Url:

https://api.istex.fr/ark:/67375/6H6-GZKMNGXR-6/fulltext.pdf

DOI: 10.1016/0264-410X(95)92777-Y

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: We have investigated the potential of the conserved transmembrane M2 protein of influenza A/Ann Arbor/6/60 virus, expressed by a baculovirus recombinant, to induce protective immunity in BALB c mice. Vaccination of mice with shortened the duration of virus shedding and protected mice from a lethal infection with A/Ann Arbor/6/60 virus but not B/Ann Arbor/1/55 virus, suggesting that the protection was mediated by an M2-specific mechanism. Serum antibodies were detected which reacted with synthetic peptides defining three antigenic determinants located on both the external N- and internal C-termini of the M2 protein. Furthermore, vaccination with M2 protected mice from death following a lethal challenge with the heterologous A/Hong Kong/68 (H3N2) virus. These results demonstrate the potential to elicit heterosubtypic immunity to type A influenza viruses through vaccination with a conserved transmembrane protein.</div>
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Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein

Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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